Within a very short time, SARMS have gone from little-known, research chemicals with strange alphanumeric names to a more popular alternative for money-guzzling supplements.
They are all over the internet today.
And most people who use them, tout them to be the side-effect free way to that buffed up physique that was always the domain of the roid user.
No more needles. No more bitch tits. Just rock hard muscles.
If you have ever considered dabbling in SARMS yourself (most athletes, bodybuilders and gym rats have), then Cardarine (GW501516) is a name that you’ll frequently come across in SARMS literature.
That’s because it is one of the most widely talked-about (possibly even the most widely used) SARMS in the world.
The most popular SARM of all?
It boosts endurance, increases fat loss, boosts muscle growth, helps reduce the levels of bad cholesterol in the body and improves recovery time after vigorous exercise.
Without any side effects at all.
Did we catch you drooling?
Just hold on to your horses. There’s more to it than what catches the eye.
Today, we decode Cardarine for you.
We sift through the hype, the fake testimonials and give you the real, unbiased scientific dope on this incredibly powerful compound.
What is Cardarine?
Also called Enduburol or available in the black market under one of its chemical names, GW1516, GW 501516, GW 501,516 and GSK-516, Cardarine is a research chemical that was developed by GSK for improving cardiac health and reducing inflammation.
Multiple animal-based clinical studies were conducted which showed remarkable promise.
For a while, scientists believed Cardarine to be the be-all, end-all of medical research for multiple conditions like heart disease, diabetes, muscle wasting and obesity.
But in Phase-II of the studies, it was discovered that at extremely high doses and extended timeframes, Cardarine triggered cancer growth in mice. (More on this later…the latest study on GW501516 will shock you!)
The keyword here is ‘extended’. Just about everything about that particular study was exaggerated. Be it the dose, or the time frame, it was way beyond what any human would use.
As luck would have it, both animal and human studies were suddenly discontinued.
The drug was banned by the WADA and most other professional sporting authorities.
At least two athletes, Valery Kaykov & Elena Lashmanova were suspended for using Cardarine.
But the results were too good to ignore and they were already public.
And anything that WADA sweeps under the rug automatically catches the attention of people looking for some extra juice.
Cardarine eventually found its way into the bodybuilding and athletic circuit much to the delight of the community.
Now, it is often stacked together with other SARMS like Ostarine (MK-2866), Andarine (S-4) and SR9009.
What’s funny though, is that it’s not a SARM itself.
Instead, it’s a PPAR delta activator that works similarly to other SARMS and to some anabolic steroids.
How does Cardarine work in the body?
Cardarine binds to the Peroxisome Proliferator Activator Receptor Delta (PPAR delta) and activates it.
This in turn fires up specific genes in the brain, muscle tissues all over the body and the heart thereby reducing inflammation, boosting lipolysis, promoting muscle growth and improving recovery time post exercise.
That sounds pretty simple when summed up in a few words.
But that’s some serious heavy lifting that the compound does.
Almost what you’d be able to achieve with multiple anabolic steroidal compounds.
What are the benefits of using Cardarine?
We spoke about it briefly. Now let’s talk about in detail.
Cardarine allows the body to use stored fat as an energy source. For a bodybuilder on a cutting cycle, that’s one way to prevent the body from cannibalizing hard earned muscle. For someone who’s obese, Cardarine might be the safer alternative to jitter-causing fat burners.
Multiple clinical studies have proven that at low doses, Cardarine can help increase the levels of HDL in the body while helping reduce triglycerides. If you are on an anabolic steroid cycle that is causing your lipid levels to go haywire, Cardarine can complement it and help keep the levels in check. That’s an added bonus to the other amazing benefits that it offers. Also, it helps reduce oxidative damage caused in blood vessels and prevents plaque from building up.
Cardarine gives you a consistent energy boost that allows you to stay focused and lift harder. There’s no sudden energy spike followed by a crash. It’s a steady flow of energy that keeps you charged for your workouts at any time of the day. Be it fasting cardio or intermittent fasting, you dont feel pooped while on it.
Brain and Kidney:
Cardarine helps prevent oxidative damage and inflammation caused in the brain due to stress and aging.
It helps prevent insulin resistance in the liver and is liver protective in conditions like diabetes.
Increased muscle mass:
This one hits the ball out of the park. Cardarine helps increase lean muscle fiber without water retention. The increased muscle fibers directly help boost performance. Let’s say you are a sprinter. Think about thick, hard muscle fibers in the legs which will allow you to run faster.
Is Cardarine safe?
The recommended dosage (by users) for Cardarine is 10mg/day.
It has a half-life of about 16-24 hours.
Some users have increased the dose to 20mg/day and claim to have achieved better results with the dose split to two times, once in the AM and once in the night.
But why risk it when you can get excellent results at the lowest dose?
Moreover, there are zero side effects reported at the 10mg/day dose.
Having said that, it’s too early to determine whether the compound can cause any long term side effects.
Can Cardarine cause cancer?
The only thing that can link Cardarine to potential cancer growth is a clinical study conducted on mice which showed that it led to an increase in cancers in the colon.
However, the dose used for that study was 1000 times the recommended dose for mice.
Here is what the same group of researchers concluded in their latest study on GW501516:
Our results not only support the rationale for developing PPARδ antagonists for use in cancer prevention and/or treatment but also establish a potential molecular basis for understanding of the epidemiologic association between obesity and the relative risk of colorectal cancer. – Crosstalk between peroxisome proliferator-activated receptor δ and VEGF stimulates cancer progression
To sum it up
Cardarine is an incredible compound that can have a profound beneficial effect on the entire body.
It improves brain health, protects your liver and kidney, boosts muscle growth, increases energy, helps your body recover sooner and stacks beautifully with other SARMS.
It does come with a risk of undetected side effects, particularly at high doses.
At safe dosage levels though, it seems to be well tolerated.